| ncRNA name | hVEGF5 siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Mus musculus |
| Tissues/Cell_line | mouse eyes |
| Methods | siRNA injection, ELISA, dextran-fluorescein perfusion, histological analysis |
| Expression pattern | associated |
| Functional description | SiRNAs directed against hVEGF effectively and specifically inhibit hypoxia-induced VEGF levels in human cell lines and after adenoviral induced hVEGF transgene expression in vivo. In addition, subretinal delivery of siRNA directed against murine Vegf significantly inhibited CNV after laser photocoagulation. |
| PubMed ID | 12789138 |
| Year | 2003 |
| Title | Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. |
| Drug-related ncRNA | NO |
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